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Your body needs time to adjust to each: GLP-1 receptor: Slows gastric emptying, reduces appetite GIP receptor: Enhances insulin signaling, affects fat metabolism Glucagon receptor: Increases energy expenditure, promotes fat oxidation Jumping to high doses overwhelms these systems, causing: Severe nausea and vomiting Treatment discontinuation Longer overall time to reach therapeutic doses The data: In the Phase 2 NEJM study, participants who started at 4 mg instead of 2 mg had significantly higher rates of gastrointestinal side effects
Even individuals with a lower BMI may qualify if they all have a weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol
Bibcode:1999Sci...283.2015A
Headaches triggered by hunger or low blood sugar may feel more acute and tend to ease after eating
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